𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Abnormalities in the p53 gene in tumors and cell lines of human squamous-cell carcinomas of the head and neck

✍ Scribed by Xiao-Ying Yin; Martin L. Smith; Theresa L. Whiteside; Joseph Locker; Jonas T. Johnson; Ronald B. Herberman

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
943 KB
Volume
54
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to detect and characterize 3 different phases in the p53 gene alteration: mutation (in 9/9 cases), I7p I 3 deletion (9/ 10 cases) and amplification of the non-deleted allele (9/31 cases). In SCCHN, deletion of the p53 gene was nearly always accompanied by mutation, only one cell line studied having mutation without deletion. Alterations in the p53 gene are common in SCCHN, and involve a series of genetic events which occur in sequence during tumor progression.

πŸ“œ SIMILAR VOLUMES

Functional characterization of p53 molec
Functional characterization of p53 molecules expressed in human squamous cell carcinomas of the head and neck
✍ W. Andrew Yeudall; Judit Jakus; John F. Ensley; Keith C. Robbins πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 170 KB πŸ‘ 2 views

Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this

Analysis of gene amplification in head-a
Analysis of gene amplification in head-and-neck squamous-cell carcinomas
✍ J. Helen Leonard; John H. Kearsley; Georgia Chenevix-Trench; Nicholas K. Hayward πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 656 KB

The presence of gene amplification was determined in 66 fresh head-and-neck SCC specimens using a battery of 9 different probes. Amplification of at least one gene was found in I 2 samples (18%), of which 7 were amplified at multiple loci (58%). We observed amplifications for EGFR (10% of samples) a

Effects of p53 or p27 overexpression on
Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines
✍ Dong Wook Lee; Seok-Woo Park; Soo-Yeun Park; Dae-Seog Heo; Kwang Hyun Kim; Myung πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 684 KB

## Abstract ## Background. Although cyclooxygenase‐2 (COX‐2) has been suggested to play an important role in carcinogenesis, the effects of tumor suppressors on COX‐2 gene expression and the combined antitumor effects of tumor suppressors and COX‐2 inhibitors have rarely been investigated. ## Met

P53 mutation correlates with cisplatin s
P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines
✍ Carol R. Bradford; Shaobo Zhu; Haruko Ogawa; Tetsuya Ogawa; Matthew Ubell; Ajita πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 137 KB πŸ‘ 2 views

## Background: A critical factor for successful organ preservation treatment in head and neck cancer may be selecting tumors that respond to chemotherapy and radiation. previous results in patients indicated that tumors that overexpressed p53 were more sensitive to chemotherapy than those that did