𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A universal solid support for the synthesis of 3′-thiol group containing oligonucleotides

✍ Scribed by K.C. Gupta; P. Sharma; S. Sathyanarayana; P. Kumar


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
249 KB
Volume
31
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


A Novel Oxime-Derived Solid Support for
✍ Simon M. Langenegger; Luzia Moesch; François Natt; Jonathan Hall; Robert Häner 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 92 KB 👁 1 views

## Abstract Oligonucleotides containing terminal phosphate groups serve as useful intermediates for different applications in molecular and cell biology, as well as for diagnostic purposes. The chemical synthesis of these derivatives has been an important topic of oligonucleotide research. We repor

A novel solid support for synthesis of 2
✍ Joseph S Vyle; Nicholas H Williams; Jane A Grasby 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 293 KB

Michaelis-Arbusov chemistry was used to prepare O,S-dialkyl Y-O-nucleosidyl phosphorothiolate triesters in solution and attached to CPG. The support-bound nucleoside was utilised in the synthesis of a pentaribonucleotide that was fully deprotected on the support. Subsequent ~'eatment with a buffere

A novel solid support for synthesis of 3
✍ Andrei Guzaev; Harri Lönnberg 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 244 KB

A novel solid phase synthesis of 3'-phosphorylated oligonuclcotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonueleotide in solution. The applicability of the method is demonstrated by preparation