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A novel solid support for synthesis of 3′-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages

✍ Scribed by Andrei Guzaev; Harri Lönnberg

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 244 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00739-9

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✦ Synopsis

A novel solid phase synthesis of 3'-phosphorylated oligonuclcotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonueleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonueleotides containing methyl phosphotriester and methyl phosphonate internuelcosidie linkages.

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## Abstract Oligonucleotides containing terminal phosphate groups serve as useful intermediates for different applications in molecular and cell biology, as well as for diagnostic purposes. The chemical synthesis of these derivatives has been an important topic of oligonucleotide research. We repor