𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A trifunctional steroid-based scaffold for combinatorial chemistry

✍ Scribed by John F. Barry; Anthony P. Davis; M. Nieves Pérez-Payan; Mark R.J. Elsegood; Richard F.W. Jackson; Cesare Gennari; Umberto Piarulli; Markus Gude

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
218 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The steroid 3, with three independently-addressable, rigidly-positioned functional groups, has been synthesized in an efficient, multi-gram sequence from inexpensive cholic acid 1. Compound 3 should prove valuable as a starting point for combinatorial libraries with preorganised, co-directed arrays of substituents.

📜 SIMILAR VOLUMES

A novel isoxazole-based scaffold for com
A novel isoxazole-based scaffold for combinatorial chemistry
✍ S Batra; S.K Rastogi; B Kundu; A Patra; A.P Bhaduri 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 137 KB

A novel isoxazole-based scaold has been identi®ed for the generation of combinatorial libraries using solid-phase methods. This scaold has been utilized to aord high value synthetic intermediates through Baylis±Hillman reaction, Wittig reaction, nitroaldol condensation, and imine and oxime formation

The Design and Synthesis of a Scaffold f
The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid
✍ Dr. Günther Wess; Klaus Bock; Horst Kleine; Dr. Michael Kurz; Dr. Wolfgang Guba; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB 👁 2 views

Combinatorial chemistry opens up new possibilities for research in medicinal chemistry in both the search for lead structures and their rapid optimization.['] Nevertheless, though many peptides are already the first milestones along this path, the optimization of sequences suitable for their combina

ChemInform Abstract: The Design and Synt
ChemInform Abstract: The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid.
✍ G. WESS; K. BOCK; H. KLEINE; M. KURZ; W. GUBA; H. HEMMERLE; E. LOPEZ-CALLE; K.-H 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid. -Starting from chenodeoxycholic acid the compound (I) is prepared, which is coupled with a polymer support. In this form the obtained derivative is a highly suitable building block for compound libraries of β-turn