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ChemInform Abstract: The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid.

✍ Scribed by G. WESS; K. BOCK; H. KLEINE; M. KURZ; W. GUBA; H. HEMMERLE; E. LOPEZ-CALLE; K.-H. BARINGHAUS; H. GLOMBIK; A. ENHSEN; W. KRAMER

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid. -Starting from chenodeoxycholic acid the compound (I) is prepared, which is coupled with a polymer support. In this form the obtained derivative is a highly suitable building block for compound libraries of Ξ²-turn peptide mimics. -(WESS, G.;

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The Design and Synthesis of a Scaffold f
The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid
✍ Dr. GΓΌnther Wess; Klaus Bock; Horst Kleine; Dr. Michael Kurz; Dr. Wolfgang Guba; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 432 KB πŸ‘ 2 views

Combinatorial chemistry opens up new possibilities for research in medicinal chemistry in both the search for lead structures and their rapid optimization.['] Nevertheless, though many peptides are already the first milestones along this path, the optimization of sequences suitable for their combina