Design, Synthesis, and Biological Evaluation of a Scaffold for iGluR Ligands Based on the Structure of (-)-Dysiherbaine.

Synthesis and Biological Evaluation of N

Synthesis and Biological Evaluation of New Conformationally Biased Integrin Ligands Based on a Tetrahydroazoninone Scaffold [cf. (VII)].

✍ Luca Banfi; Andrea Basso; Gianluca Damonte; Federico De Pellegrini; Andrea Galat 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

The Design and Synthesis of a Scaffold f

The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid

✍ Dr. Günther Wess; Klaus Bock; Horst Kleine; Dr. Michael Kurz; Dr. Wolfgang Guba; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB 👁 2 views

Combinatorial chemistry opens up new possibilities for research in medicinal chemistry in both the search for lead structures and their rapid optimization.['] Nevertheless, though many peptides are already the first milestones along this path, the optimization of sequences suitable for their combina

Design In Silico, Synthesis and Binding

Design In Silico, Synthesis and Binding Evaluation of a Carbohydrate-Based Scaffold for Structurally Novel Inhibitors of Matrix Metalloproteinases

✍ Marco Fragai; Cristina Nativi; Barbara Richichi; Chiara Venturi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 2 views

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

Design, Synthesis, and Biological Evalua

Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold

✍ Jürgen Boer; Dirk Gottschling; Anja Schuster; Bernhard Holzmann; Horst Kessler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 1 views

The tuning of protein ± protein interactions by small nonpeptidic molecules remains one of the great challenges in medicinal chemistry. Although already proposed in 1980 by Farmer, [1] only a few successful examples on the synthesis of peptidomimetics based on rigid scaffolds such as cyclohexane and

ChemInform Abstract: The Design and Synt

ChemInform Abstract: The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid.

✍ G. WESS; K. BOCK; H. KLEINE; M. KURZ; W. GUBA; H. HEMMERLE; E. LOPEZ-CALLE; K.-H 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid. -Starting from chenodeoxycholic acid the compound (I) is prepared, which is coupled with a polymer support. In this form the obtained derivative is a highly suitable building block for compound libraries of β-turn