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A novel isoxazole-based scaffold for combinatorial chemistry

โœ Scribed by S Batra; S.K Rastogi; B Kundu; A Patra; A.P Bhaduri

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
137 KB
Volume
41
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A novel isoxazole-based scaold has been identiยฎed for the generation of combinatorial libraries using solid-phase methods. This scaold has been utilized to aord high value synthetic intermediates through BaylisยฑHillman reaction, Wittig reaction, nitroaldol condensation, and imine and oxime formation. The utility of the scaold has been demonstrated by synthesizing a small library of 32 isoxazole substituted g-amino alcohol using four activated alkenes and eight amines.

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