A total synthesis of the naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A
โ Scribed by Eric A. Meade; Steven H. Krawczyk; Leroy B. Townsend*
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 196 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The first total synthesis of mycalisine A, a pyrrolo[2,3-dlpyrimidine nucleoside, was accomplished by a multi-step synthesis from toyocamycin.
๐ SIMILAR VOLUMES
A total synthesis of 2-amino-7-(O-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidin-4-one-5-carboxylic acid has been accomplished and confirms the previous structural assignment for the nucleoside antibiotic cadeguomycin.
1-Methylisoguanosine was synthesized by a one-pot reaction involving a condensation of 5-amino-l-(L3-D-ribofuranosyl)imidazole-4-carboxamide (1) with methyl isothiocyanate, treatment of the resulting thiourea derivative with DCC furnished 5-(3-methyl-1-ureidol-l-(&gribofuranosyl)imidazole-4-carbonit
We wish to report the synthesis of a new tricyclic ring system, pyrazolo[3',~'-5,4]pyrrolo[2,3-d]pyrimidine, by a unique ring closure procedure. In the course of our investigation of the chemistry of the pyrrolo[2,3-dJl~rrimidine nueleoside antibiotics, 3 tubercidin, toyocamycin,