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Pyrrolopyrimidine nucleosides 19. A total synthesis of the nucleoside antibiotic cadeguomycin [2-amino-7-(β-d-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one-5-carboxylic acid]

✍ Scribed by Vladimir G Beylin; Andrew M Kawasaki; Chin Shu Cheng; Leroy B Townsend

Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
220 KB
Volume
24
Category
Article
ISSN
0040-4039

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✦ Synopsis

A total synthesis of 2-amino-7-(O-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidin-4-one-5-carboxylic acid has been accomplished and confirms the previous structural assignment for the nucleoside antibiotic cadeguomycin.

📜 SIMILAR VOLUMES

The synthesis of 4,5-diamino-8-β-D-ribof
The synthesis of 4,5-diamino-8-β-D-ribofuranosylpyrazolo[3′,4′-5,4]pyrrolo[2,3-d]pyrimidine, a novel tricyclic nucleoside
✍ Richard L. Tolman; Leroy B. Townsend 📂 Article 📅 1968 🏛 Elsevier Science 🌐 French ⚖ 165 KB

We wish to report the synthesis of a new tricyclic ring system, pyrazolo[3',~'-5,4]pyrrolo[2,3-d]pyrimidine, by a unique ring closure procedure. In the course of our investigation of the chemistry of the pyrrolo[2,3-dJl~rrimidine nueleoside antibiotics, 3 tubercidin, toyocamycin,

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The synthesis of 6-amino-4-methyl-8-(β-D-ribofuranosyl) (4-H,8-H)pyrrolo-[4,3,2-de]pyrimido[4,5-c]pyridazine, a new tricyclic nucleoside
✍ Karl H. Schram; Leroy B. Townsend 📂 Article 📅 1971 🏛 Elsevier Science 🌐 French ⚖ 240 KB

We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B