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The synthesis of 6-amino-4-methyl-8-(β-D-ribofuranosyl) (4-H,8-H)pyrrolo-[4,3,2-de]pyrimido[4,5-c]pyridazine, a new tricyclic nucleoside

✍ Scribed by Karl H. Schram; Leroy B. Townsend

Publisher
Elsevier Science
Year
1971
Tongue
French
Weight
240 KB
Volume
12
Category
Article
ISSN
0040-4039

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✦ Synopsis

We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B-D-ribo~anosyl)pyrrolo[2,3-d]pyri~dine (III). However, the absence of a peak in

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