The synthesis of 4,5-diamino-8-β-D-ribofuranosylpyrazolo[3′,4′-5,4]pyrrolo[2,3-d]pyrimidine, a novel tricyclic nucleoside
✍ Scribed by Richard L. Tolman; Leroy B. Townsend
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- French
- Weight
- 165 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
We wish to report the synthesis of a new tricyclic ring system, pyrazolo[3',~'-5,4]pyrrolo[2,3-d]pyrimidine, by a unique ring closure procedure. In the course of our investigation of the chemistry of the pyrrolo[2,3-dJl~rrimidine nueleoside antibiotics, 3 tubercidin, toyocamycin,
📜 SIMILAR VOLUMES
We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B
## Abstract Derivatives of the new ring system pyrrolo[3,4‐__e__][1,2,3] triazolo[1,5‐__a__]pyrimidine **6** were prepared in high yields in one step by reaction of 3‐azidopyrrole **3** and substituted acetonitriles. Compound **6b** rearranged, upon heating in dimethyl sulfoxide in the presence of
A total synthesis of 2-amino-7-(O-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidin-4-one-5-carboxylic acid has been accomplished and confirms the previous structural assignment for the nucleoside antibiotic cadeguomycin.