We wish to report the synthesis of a new tricyclic ring system, pyrazolo[3',~'-5,4]pyrrolo[2,3-d]pyrimidine, by a unique ring closure procedure. In the course of our investigation of the chemistry of the pyrrolo[2,3-dJl~rrimidine nueleoside antibiotics, 3 tubercidin, toyocamycin,
The synthesis of 4-amino-8-(β-d-ribofuranosyl)aminopyrimido[5,4-d]pyrimidine from a purine nucleoside: a novel rearrangement of the purine ring
✍ Scribed by Helen M. Berman; Robert J. Rousseau; Robert W. Mancuso; George P. Kreishman; Roland K. Robins
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 143 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Treatment of 7-(2,3,5-tris-Q-(t-butyldimethylsilyl)-R~-~~f~osyl)i~dazo[4,5-~-v-~az~-4-one (1) with Mn@ in hot pyridine furnished 7-(2,3,5-tris-Q-(t-butyldimethylsilyl)-0do[ 1,2-a]purine (4). Treatment of 4 with tetra-a-butylammonium fluoride furnished the free nucleoside 5. Tricyclic nucleosides are
A total synthesis of 2-amino-7-(O-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidin-4-one-5-carboxylic acid has been accomplished and confirms the previous structural assignment for the nucleoside antibiotic cadeguomycin.
We would like to report the synthesis of a derivative of the new heterocyclic ring system pyrrolo[4,3,2-de]pyrimido[4,5-clpyridazine. The reaction of 4-chloro-5-cyano-7-(g-D-ribofuranosyl)pyrrolo[2,3-dlpyrimidine (I) (3) with methylhydrasine should have furnished 5-cyano-4-(N-l-methylhydrazino)-7-(B
etrahedron ia !: ters No. 13, pp. lOlj-1015, 1')70. [email protected] i'ress. Printed in Great Britain.