✦ LIBER ✦

A novel and efficient synthesis of the naturally occurring nucleoside doridosine

✍ Scribed by Ji-Wang Chern; Leroy B. Townsend

Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 264 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)99016-6

No coin nor oath required. For personal study only.

✦ Synopsis

1-Methylisoguanosine was synthesized by a one-pot reaction involving a condensation of 5-amino-l-(L3-D-ribofuranosyl)imidazole-4-carboxamide (1) with methyl isothiocyanate, treatment of the resulting thiourea derivative with DCC furnished 5-(3-methyl-1-ureidol-l-(&gribofuranosyl)imidazole-4-carbonitrile ($1 which was then annulated with ethanolic ammonia to furnish doridosine in a 68% yield from 1. l-Methylisoguanosine (2, doridosine. 6-amino-l-methy1-9-fi-~-ribofuranosylpurin-2-one) was recently isolated from three different marine animals by three independent laboratories. 2-4 This compound has been shown to possess potent muscle-relaxant activity, as well as a lowering

📜 SIMILAR VOLUMES

A total synthesis of the naturally occur

A total synthesis of the naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A

✍ Eric A. Meade; Steven H. Krawczyk; Leroy B. Townsend* 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 196 KB

The first total synthesis of mycalisine A, a pyrrolo[2,3-dlpyrimidine nucleoside, was accomplished by a multi-step synthesis from toyocamycin.

The Synthesis of Naturally Occurring ()-

The Synthesis of Naturally Occurring ()-Calyculin A

✍ Dr. Norihiko Tánimoto; Dr. Samuel W. Gerritz; Dr. Akiyoshi Sawabe; Dr. Takeshi N 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB 👁 2 views

An efficient and enantioselective total

An efficient and enantioselective total synthesis of naturally occurring L-783277

✍ Hwan Geun Choi; Jung Beom Son; Dong-Sik Park; Young Jin Ham; Jung-Mi Hah; Taebo 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 844 KB

Novel and Stereocontrolled Asymmetric Sy

Novel and Stereocontrolled Asymmetric Synthesis of a New Naturally Occurring Styryllactone, (+)-Cardiobutanolide.

✍ Daisuke Matsuura; Kunihiko Takabe; Hidemi Yoda 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views

A novel and short synthesis of naturally

A novel and short synthesis of naturally occurring 5-(3′-indolyl)oxazoles

✍ Dalip Kumar; Swapna Sundaree; Gautam Patel; Anil Kumar 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 117 KB 👁 1 views

## Abstract magnified image A novel, concise, and convenient synthesis of 5‐(3′‐indolyl)oxazoles using relatively benign reagent [hydroxy(2,4‐dinitrobenzenesulfonyloxy)iodo]benezene has been described. The advantages of this procedure include operational simplicity, good yield, and avoidance of the

Synthesis and characterization of a nove

Synthesis and characterization of a novel chitosan-based network prepared using naturally occurring crosslinker

✍ Fwu-Long Mi; Hsing-Wen Sung; Shin-Shing Shyu 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 297 KB 👁 2 views