Total synthesis of 2′-deoxycadeguomycin, a new pyrrolo[2,3-d]pyrimidine nucleotide analogue
✍ Scribed by Eric D. Edstrom; Yuan Wei
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 142 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The first total synthesis of mycalisine A, a pyrrolo[2,3-dlpyrimidine nucleoside, was accomplished by a multi-step synthesis from toyocamycin.
We have developed a new methodology for the construction of 5-substituted pyrrolo [2,3-d]pyrimidines that involves the reduction of a nitroalkane to an oxime using the reducing ability of the Sn(SR 3 ) -species, followed by mild, acid-catalysed deoximation of the resulting adduct using Dowex-H + res
## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^α^‐[4‐[__N__‐[(2,4‐diaminopyrrolo[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐__N__^δ^‐hemiphthaloyl‐L‐ornithine **(7)**, __N__^α^‐ [4‐ [__N__‐[(2,4‐diaminothieno[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐