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A total synthesis of leukotriene F4 (LTF4)

โœ Scribed by Frank Ellis; Lester S Mills; Peter C North

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
143 KB
Volume
23
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The synthesis of LTF4 via the reaction of (+)-leukotrlene A4(LTA4), mett-il ester 1 with the protected glutamylcystelne 1 1s reported

The leukotrienes LTC4, D4 and E4 are a recently dlscovered family of arachldonlc acid metabolltes which are thought to be involved in certain hypersensitlvlty reactlons including allergic asthma ' It was recently disclosed2 that incubation of LTE4 with Zf-glutamyl transpeptldase, in the presence of glutathlone, produces a new leukotrlene (LTF4) possessing

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