𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of leukotrienes - new synthesis of natural leukotriene A4

✍ Scribed by Joshua Rokach; Robert N. Young; Masatoshi Kakushima


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
216 KB
Volume
22
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Biomimetic synthesis of leukotriene A
✍ Vince Atrache; Jin-Keon Pai; Dai-Eun Sok; Charles J. Sih πŸ“‚ Article πŸ“… 1981 πŸ› Elsevier Science 🌐 French βš– 275 KB

A bioqenetically patterned conversion of 1 into 2 is described. This transformation has been found to be non-stereospecific with respect to the geometry of the newly qenerated double bond at C-9(10). Leukotriene A (LTA), S(S)-trans-5,6-oxido-7,9-E-11,14-Z-eicosatetraenoic acid1 was shown to he an un

Synthesis of Leukotriene Analogs
✍ Bernd Spur; Attilio Crea; Wilfried Peters; Wolfgang KΓΆnig πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 153 KB πŸ‘ 1 views
Conformationally restricted leukotriene
✍ Jeffrey S. Sabol; Philip M. Weintraub; Thomas H. Gieske; Robert J. Cregge πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 385 KB

The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6

A total synthesis of leukotriene F4 (LTF
✍ Frank Ellis; Lester S Mills; Peter C North πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 143 KB

The synthesis of LTF4 via the reaction of (+)-leukotrlene A4(LTA4), mett-il ester 1 with the protected glutamylcystelne 1 1s reported The leukotrienes LTC4, D4 and E4 are a recently dlscovered family of arachldonlc acid metabolltes which are thought to be involved in certain hypersensitlvlty reactl

An efficient synthesis of leukotriene B4
✍ M. Avignon-Tropis; M. Treilhou; J. Lebreton; J.R. Pougny; I. FrΓ©chard-Ortuno; C. πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 89 KB
Stereospecific synthesis of leukotriene
✍ Yvan Guindon; Robert Zamboni; Cheuk-Kun Lau; Joshua Rokach πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 253 KB

A stereospecific and chorally economical synthesis of LTE, starting from E-deoxy-D-nbose IS reported as part of a comprehensive and efflclent approach to the Leukotnenes (A, 8, C, 0, E). The process includes a novel approach to choral dienlc synthons. Leukotnene 8, (1) IS a component of the arachldo