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A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines

✍ Scribed by Fujieda, Hiroki; Kanai, Motomu; Kambara, Takeshi; Iida, Akira; Tomioka, Kiyoshi


Book ID
121864745
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
75 KB
Volume
119
Category
Article
ISSN
0002-7863

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Systematic investigation of the varying size of the alkoxy moiety of the lithium ester enolates in the chiral ligand mediated reaction with imines led to the improvement of the enantioselectivity of I~-lactam products in up to 93%. The asymmetric induction step was indicated to be the addition step,