Enolates with Imines. -Based on a ternary complex reagent, which comprises three components, a chiral ether ligand, an achiral lithium amide and (I), the asymmetric addition of (I) to an imine (II) leads to the Ξ²-lactams such as (III) and (V) in high enantiomeric excess. The enantioselectivity and
A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines
β Scribed by Fujieda, Hiroki; Kanai, Motomu; Kambara, Takeshi; Iida, Akira; Tomioka, Kiyoshi
- Book ID
- 121864745
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 75 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0002-7863
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Systematic investigation of the varying size of the alkoxy moiety of the lithium ester enolates in the chiral ligand mediated reaction with imines led to the improvement of the enantioselectivity of I~-lactam products in up to 93%. The asymmetric induction step was indicated to be the addition step,