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NMR studies of a ternary complex reagent of lithium ester enolate, chiral diether, and lithium diisopropylamide in an asymmetric Michael reaction

✍ Scribed by Yasutomo Yamamoto; Yorinobu Yasuda; Hassan Oulyadi; Jacques Maddaluno; Kiyoshi Tomioka


Book ID
108283219
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
509 KB
Volume
66
Category
Article
ISSN
0040-4020

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Enolates with Imines. -Based on a ternary complex reagent, which comprises three components, a chiral ether ligand, an achiral lithium amide and (I), the asymmetric addition of (I) to an imine (II) leads to the Ξ²-lactams such as (III) and (V) in high enantiomeric excess. The enantioselectivity and