## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
A ternary complex reagent for an asymmetric Michael reaction of lithium ester enolates with enoates
β Scribed by Yasutomo Yamamoto; Hirokazu Suzuki; Yorinobu Yasuda; Akira Iida; Kiyoshi Tomioka
- Book ID
- 108285040
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 175 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Enolates with Imines. -Based on a ternary complex reagent, which comprises three components, a chiral ether ligand, an achiral lithium amide and (I), the asymmetric addition of (I) to an imine (II) leads to the Ξ²-lactams such as (III) and (V) in high enantiomeric excess. The enantioselectivity and
Systematic investigation of the varying size of the alkoxy moiety of the lithium ester enolates in the chiral ligand mediated reaction with imines led to the improvement of the enantioselectivity of I~-lactam products in up to 93%. The asymmetric induction step was indicated to be the addition step,
A Factor Affecting Enantioselective Reaction of a Ternary Complex of Lithium Ester Enolate with Imine. -Lithiation of esters such as (I) followed by coupling of the resulting enolates with imines [cf. (II)] in the presence of chiral ether ligands is investigated systematically. Under improved react