Enolates with Imines. -Based on a ternary complex reagent, which comprises three components, a chiral ether ligand, an achiral lithium amide and (I), the asymmetric addition of (I) to an imine (II) leads to the Ξ²-lactams such as (III) and (V) in high enantiomeric excess. The enantioselectivity and
ChemInform Abstract: A Ternary Complex Reagent for an Asymmetric Michael Reaction of Lithium Ester Enolates with Enoates.
β Scribed by Yasutomo Yamamoto; Hirokazu Suzuki; Yorinobu Yasuda; Akira Iida; Kiyoshi Tomioka
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 40 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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A Factor Affecting Enantioselective Reaction of a Ternary Complex of Lithium Ester Enolate with Imine. -Lithiation of esters such as (I) followed by coupling of the resulting enolates with imines [cf. (II)] in the presence of chiral ether ligands is investigated systematically. Under improved react