ChemInform Abstract: Catalytic Asymmetric Reaction of Lithium Ester Enolates with Imines.
β Scribed by Kiyoshi Tomioka; Hiroki Fujieda; Satoko Hayashi; Mostafa Ahmed Hussein; Takeshi Kambara; Yumiko Nomura; Motomu Kanai; Kenji Koga
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Enolates with Imines. -Based on a ternary complex reagent, which comprises three components, a chiral ether ligand, an achiral lithium amide and (I), the asymmetric addition of (I) to an imine (II) leads to the Ξ²-lactams such as (III) and (V) in high enantiomeric excess. The enantioselectivity and
A Factor Affecting Enantioselective Reaction of a Ternary Complex of Lithium Ester Enolate with Imine. -Lithiation of esters such as (I) followed by coupling of the resulting enolates with imines [cf. (II)] in the presence of chiral ether ligands is investigated systematically. Under improved react
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