A stereospecific synthesis of (4R)-4-[(E)-2-butenyl]-4, N-dimethyl-L-threonine (MeBmt)
β Scribed by A.V.Rama Rao; T.G.Murali Dhar; T.K Chakraborty; M.K Gurjar
- Book ID
- 104221247
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 205 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## cis-Oxazolidinone derivative 130) readily real&xl from chiral 2,3-epoxy alcohol (27) h3 been exploited in the synthesis of (4R)-4_i(E~-2-butenyl1-4,N~imethyl-L-threonine f2), an unusual B-hydroxyaamina acid present in cyoiosporin lhe intrirrric feature of this approach involved facile isomerisati
Addition of various amines to the 3,3-bis(trifluoromethyl)acrylamides 10a and 10b gave the tripeptides 11a -11f, mostly as mixtures of epimers (Scheme 3). The crystalline tripeptide 11f 2 was found to be the N-terminal (2-hydroxyethoxy)-substituted (R,S,S)-ester HOCH 2 CH 2 O-d-Val(F 6 )-MeLeu-Ala-O