✦ LIBER ✦
A versatile protocol for β-hydroxy-α-amino acids: an application to (4R)-4-[(e)-2-butenyl]-4n-dimethyl-l-threonine (MeBmt)
✍ Scribed by A.V.Rama Rao; T.G.Murali Dhar; D. Subhas Bose; T.K. Chakraborty; M.K. Gurjar
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 652 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
cis-Oxazolidinone derivative 130) readily real&xl from chiral 2,3-epoxy alcohol (27) h3 been exploited in the synthesis of (4R)-4_i(E~-2-butenyl1-4,N~imethyl-L-threonine f2), an unusual B-hydroxyaamina acid present in cyoiosporin lhe intrirrric feature of this approach involved facile isomerisation of cis-oxazolidinone deriwtive (31) into the Pans-isomer (32) whose hydrolysis provided s?&?%ydrary+amino
acid.