A short synthesis of the unusual amino acid of cyclosporine (4R)-4-[(E)-2-butenyl]-4,N-dimethyl-L-threonine (MeBmt)
✍ Scribed by Monique Savignac; Jean-Olivier Durand; Jean-Pierre Genêt
- Book ID
- 108036199
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 384 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
## cis-Oxazolidinone derivative 130) readily real&xl from chiral 2,3-epoxy alcohol (27) h3 been exploited in the synthesis of (4R)-4_i(E~-2-butenyl1-4,N~imethyl-L-threonine f2), an unusual B-hydroxyaamina acid present in cyoiosporin lhe intrirrric feature of this approach involved facile isomerisati
Introduction. ~ Stereoselective C-C bond forming reactions catalyzed by chiral transition-metal complexes are a topic of fundamental importance [l]. In 1986, Hayashi and Zto reported an elegant asymmetric synthesis of dihydrooxazoles by an efficient gold(1)-catalyzed coupling of aldehydes with 2-iso