Synthesis of (4R)-4-((E)-2-butenyl)-4,N-dimethyl-L-threonine (MeBMT), the characteristic amino acid of cyclosporine
β Scribed by Ulrich Schmidt; Wolfgang Siegel
- Book ID
- 108382976
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 258 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## cis-Oxazolidinone derivative 130) readily real&xl from chiral 2,3-epoxy alcohol (27) h3 been exploited in the synthesis of (4R)-4_i(E~-2-butenyl1-4,N~imethyl-L-threonine f2), an unusual B-hydroxyaamina acid present in cyoiosporin lhe intrirrric feature of this approach involved facile isomerisati
Introduction. ~ Stereoselective C-C bond forming reactions catalyzed by chiral transition-metal complexes are a topic of fundamental importance [l]. In 1986, Hayashi and Zto reported an elegant asymmetric synthesis of dihydrooxazoles by an efficient gold(1)-catalyzed coupling of aldehydes with 2-iso