## Abstract Starting from __R__,__R__‐(+)‐tartaric acid, the synthesis of (2__S__,3__R__,4__R__6__E__)‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid in 24 steps is reported. This novel amino acid is found in the cyclic undecapeptide cyclosporin A, isolated from the fungal strain __Tolypocladium
An enantioselective solutions towards synthesizing “skip” 1,3 dimethyl stereocenters. A synthesis of 4S(2E,4R∗,6R∗)-4,6-Dimethyl-2-octenoic acid
✍ Scribed by Richard H. Schlessinger; Kevin W. Gillman
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 266 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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The chiral aldehyde 7 was prepared by diastereoselective alkylation, subsequent 1,2addition of isopropenylmagnesium bromide gave rise to a mixture (68:32) of the allylic alcohols 8 and 10 which was separated by recycling MPLC. Claisen rearrangement of the propionates of
## Abstract The now corrected X‐ray structure of (2__R__)‐bornane‐10,2‐sultam ((−)‐**1a**), as well as that of its already published __N__‐crotonoyl derivative (−)‐**1d**, were compared with those of the newly synthesized (2__R__)‐fenchane‐8,2‐sultam ((+)‐**5a**), as well as its __N__‐crotonoyl der