✦ LIBER ✦

A short synthesis of 5-amino[4-14]laevulinic acid hydrochloride

✍ Scribed by J B Cambell; J S Johnston

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 219 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580271202

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✦ Synopsis

5-Amin0[4-'~C]laevulinic

acid hydrochloride has been prepared from potassium [14C]cyanide in 56% overall yield. The key step is the palladium[O] catalysed coupling of 2-phthalimid0[l-'~C]acetyl chloride with 2-carboethoxyethylzinc iodide to give 5-phthalimid0[4-'~C]laevulinic acid ethyl ester in 86% yield. The synthesis was carried out at high specific activity from J20mCi of starting material.

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