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A phase I–II study of 14-days continuous infusion of 5-fluorouracil with weekly bolus leucovorin in metastatic colorectal carcinoma

✍ Scribed by Sinnige, Harm A.M.; Nanninga, Afien G.; Verschueren, Rene C.J.; Sleijfer, Dirk Th.; de Vries, Elisabeth G.E.; Willemse, Pax H.B.; Mulder, Nanno H.

Book ID
123353563
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
535 KB
Volume
28
Category
Article
ISSN
0959-8049

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A phase II trial of weekly high dose con
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✍ Enrique Aranda; Andrés Cervantes; Javier Dorta; Esperanza Blanco; Carlos Fernánd 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 419 KB 👁 2 views

Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer