Randomised comparison of weekly bolus 5-fluorouracil with or without leucovorin in metastatic colorectal carcinoma
โ Scribed by Nobile, M.T; Rosso, R; Sertoli, M.R; Rubagotti, A; Vidili, M.G; Guglielmi, A; Venturini, M; Canobbio, L; Fassio, T; Gallo, L
- Book ID
- 122787373
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 618 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0959-8049
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## Background: Colorectal carcinoma is the third leading cause of cancer-related death. the primary treatment for patients with metastatic colorectal carcinoma is systemic chemotherapy with 5-fluorouracil (5-fu) and leucovorin (lv), a biomodulator of 5-fu that has been shown to enhance its activity
Thirty-eight patients with metastatic colorecal carcinoma were treated with 5-fluorouracil (5-FU), and 38 patients were treated with the combination of 5-FU, cyclophosphamide, and methotrexate. In terms of percent response, response duration, and survival there was no apparent difference between the