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Phase I trial of a 5-day infusion ofL-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies

✍ Scribed by Frank H. Valone; David R. Gandara; Judith A. Luce; Susan Wall; Edith A. Perez; Natalie Braham; Martine George; Laurie Letvak

Publisher
Springer
Year
1993
Tongue
English
Weight
647 KB
Volume
32
Category
Article
ISSN
0344-5704

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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer