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A novel synthesis of oxanosine and 1-thiaguanosine

✍ Scribed by Kin-Chun Luk; Douglas W. Moore; Dennis D. Keith

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 288 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79951-5

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✦ Synopsis

Akfrad: A novel total synthesis of oxanosinc has been dcvclopcd. The key hctcrocyclc forming reaction of this synthesis is the carbodiimidc mediated dehydration and cyclization of an urea-acid derived from AICA-riboside. The same procedure was also applied to the synthesis of I-thiaguanosine.

Oxanosine (1) is a nucleoside antibiotic isolated from Streptomyces capreolus MG265-CF3,2 with antimicrobial and carcinostatic activities .3.4*5.6 Its structure was determined by single crystal X-ray analysis.7

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