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First synthesis of enantiomerically pure carbocyclic oxanosine as a potential chemotherapeutic agent

✍ Scribed by Hiroko Kurata; Shigeru Nishiyama; Shosuke Yamamura; Kuniki Kato; Sari Fujiwara; Kazuo Umezawa


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
186 KB
Volume
6
Category
Article
ISSN
0960-894X

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✍ Bai-Chuan Pan; Yung-Chi Cheng; Shih-Hsi Chu πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 519 KB

## Abstract A novel class of nucleosides with the C~1~, atom bonded to three hetero atoms was synthesized. 2′‐Thia‐2β€²,3′‐dideoxycytidine was the pilot compound of this series. (Β±)‐β‐2′‐Thia‐1β€²,3′‐dideoxycytidine (6) and (Β±)‐α‐2′‐thia‐2β€²,3′‐dideoxycytidine (7) were synthesized from (Β±)‐3‐mercapto‐1,