Akfrad: A novel total synthesis of oxanosinc has been dcvclopcd. The key hctcrocyclc forming reaction of this synthesis is the carbodiimidc mediated dehydration and cyclization of an urea-acid derived from AICA-riboside. The same procedure was also applied to the synthesis of I-thiaguanosine. Oxano
A facile total synthesis of oxanosine, a novel nucleoside antibiotic
β Scribed by Naomasa Yagisawa; Tomohisa Takita; Hamao Umezawa; Kuniki Kato; Nobuyoshi Shimada
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 98 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The total synthesis of oxanosine, a novel nucleoside antibiotic, has been achieved for the first time.
Oxanosine ( ) is a novel nucleoside antibiotic isolated from the culture filtrate of Streptomyces capreolus MG265-CF3.
1
The structure was determined to be 5-amino-3-p-D-ribofurano-
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The total synthesis of the naturally occurring cyclic hexadepsipeptide antibiotic L-156.602 (1) is L-156602 (l), isolated from cultums of Streptomyces spp. MA6348,2 represents a novel 19membered cyclic hexadepsipeptide antibiotic closely related to axinothricin~ and A83586C3b and, based on compariso