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A novel JAK2 splicing mutation in neonatal myeloproliferative disorder accompanying congenital anomalies

✍ Scribed by Hiroaki Ohnishi; Ken-ichirou Hosoi; Hiroshi Yoshino; Masatoshi Sugiura; Satsuki Matsushima; Takashi Watanabe; Fumio Bessho

Book ID
108676276
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
158 KB
Volume
145
Category
Article
ISSN
0007-1048

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A Gain-of-Function Mutation of JAK2 in M
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders
✍ Kralovics, Robert; Passamonti, Francesco; Buser, Andreas S.; Teo, Soon-Siong; Ti πŸ“‚ Article πŸ“… 2005 πŸ› Massachusetts Medical Society 🌐 English βš– 521 KB

## background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors