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A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects

✍ Scribed by Chloé James; Valérie Ugo; Nicole Casadevall; Stefan N. Constantinescu; William Vainchenker


Book ID
116757980
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
362 KB
Volume
11
Category
Article
ISSN
1471-4914

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A Gain-of-Function Mutation of JAK2 in M
✍ Kralovics, Robert; Passamonti, Francesco; Buser, Andreas S.; Teo, Soon-Siong; Ti 📂 Article 📅 2005 🏛 Massachusetts Medical Society 🌐 English ⚖ 521 KB

## background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors