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A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders

✍ Scribed by Kralovics, Robert; Passamonti, Francesco; Buser, Andreas S.; Teo, Soon-Siong; Tiedt, Ralph; Passweg, Jakob R.; Tichelli, Andre; Cazzola, Mario; Skoda, Radek C.

Book ID
121494469
Publisher
Massachusetts Medical Society
Year
2005
Tongue
English
Weight
521 KB
Volume
352
Category
Article
ISSN
0096-6762

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A Gain-of-Function Mutation of JAK2 in M
A Gain-of-Function Mutation of JAK2 in Myeloproliferative Disorders
✍ Kralovics, Robert; Passamonti, Francesco; Buser, Andreas S.; Teo, Soon-Siong; Ti πŸ“‚ Article πŸ“… 2005 πŸ› Massachusetts Medical Society 🌐 English βš– 521 KB

## background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors