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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

โœ Scribed by E Joanna Baxter; Linda M Scott; Peter J Campbell; Clare East; Nasios Fourouclas; Soheila Swanton; George S Vassiliou; Anthony J Bench; Elaine M Boyd; Natasha Curtin; Mike A Scott; Wendy N Erber; Anthony R Green


Book ID
117291137
Publisher
The Lancet
Year
2005
Tongue
English
Weight
258 KB
Volume
365
Category
Article
ISSN
0140-6736

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๐Ÿ“œ SIMILAR VOLUMES


A Gain-of-Function Mutation of JAK2 in M
โœ Kralovics, Robert; Passamonti, Francesco; Buser, Andreas S.; Teo, Soon-Siong; Ti ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Massachusetts Medical Society ๐ŸŒ English โš– 521 KB

## background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors