A novel approach towards the synthesis of the 3,4,5-trihydro-1,3-diazepin-5-ol ring structure
β Scribed by Oscar L. Acevedo; Steven H. Krawczyk; Leroy B. Townsend
- Book ID
- 108382336
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 218 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC 50 's against prostate, lung, breast, and ovarian cancer
## Abstract The synthesis of 6βaminoβ4,5βdihydroβ8__H__β1β(2βphosphonylmethoxyethyl)imidazo[4,5β__e__][1,3]diazepineβ4,8βdione (7), a novel ringβexpanded (βfatβ) acyclic nucleotide analogue of phosphonomethoxyethylguanine (PMEG), has been reported. It was prepared in 4 steps in 51% overall yield st
An expedient synthesis of 8-acylamidopyrazolo[1,5-a]-1,3,5-triazines was developed by treating 8-amino-4-[N-(4aminophenyl)-N-(methyl)amino]pyrazolo[1,5-a]-1,3,5-triazine with various acyl chlorides following by the displacement of the so-formed N-(methyl)-N-[4-(acylamido)phenyl]amino leaving group w