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A general approach toward the synthesis of 8-acylamidopyrazolo[1,5-a]-1,3,5-triazines

✍ Scribed by Pierre Raboisson; Dominique Schultz; Claire Lugnier; Romain Mathieu; Jean-Jacques Bourguignon

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 143 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02661-8

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✦ Synopsis

An expedient synthesis of 8-acylamidopyrazolo[1,5-a]-1,3,5-triazines was developed by treating 8-amino-4-[N-(4aminophenyl)-N-(methyl)amino]pyrazolo[1,5-a]-1,3,5-triazine with various acyl chlorides following by the displacement of the so-formed N-(methyl)-N-[4-(acylamido)phenyl]amino leaving group with various amines. Applications to high-throughput synthesis are suggested.

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