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Synthesis of a novel ring-expanded (“fat”) nucleotide analogue of phosphonomethoxyethylguanine (PMEG) containing the imidazo[4,5-e][1,3]diazepine ring system

✍ Scribed by Huan-Ming Chen; Ramachandra S. Hosmane

Publisher: Journal of Heterocyclic Chemistry
Year: 2001
Tongue: English
Weight: 33 KB
Volume: 38
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570380611

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✦ Synopsis

Abstract

The synthesis of 6‐amino‐4,5‐dihydro‐8__H__‐1‐(2‐phosphonylmethoxyethyl)imidazo[4,5‐e][1,3]diazepine‐4,8‐dione (7), a novel ring‐expanded (“fat”) acyclic nucleotide analogue of phosphonomethoxyethylguanine (PMEG), has been reported. It was prepared in 4 steps in 51% overall yield starting from dimethyl imida‐zole‐4,5‐dicarboxylate.

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