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ChemInform Abstract: Potent in vitro Anticancer Activities of Ring-Expanded (“fat”) Nucleosides Containing the Imidazo[4,5-E][1,3]diazepine Ring System

✍ Scribed by Juliana K. Gill; Lijuan Wang; Maria Bretner; Rachel Newman; Natasha Kyprianou; Ramachandra S. Hosmane

Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of a Nove
ChemInform Abstract: Synthesis of a Novel Ring-Expanded (“Fat”) Nucleotide Analogue of Phosphonomethoxyethylguanine (PMEG) Containing the Imidazo[4,5-e][1,3]diazepine Ring System.
✍ Huan-Ming Chen; Ramachandra S. Hosmane 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 3 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis of a novel ring-expanded (“fat
Synthesis of a novel ring-expanded (“fat”) nucleotide analogue of phosphonomethoxyethylguanine (PMEG) containing the imidazo[4,5-e][1,3]diazepine ring system
✍ Huan-Ming Chen; Ramachandra S. Hosmane 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 33 KB

## Abstract The synthesis of 6‐amino‐4,5‐dihydro‐8__H__‐1‐(2‐phosphonylmethoxyethyl)imidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (7), a novel ring‐expanded (“fat”) acyclic nucleotide analogue of phosphonomethoxyethylguanine (PMEG), has been reported. It was prepared in 4 steps in 51% overall yield st