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A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system

✍ Scribed by Min Xie; Ravi K. Ujjinamatada; Mariola Sadowska; Rena G. Lapidus; Martin J. Edelman; Ramachandra S. Hosmane

Book ID: 104004540
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 478 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.06.061

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✦ Synopsis

Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC 50 's against prostate, lung, breast, and ovarian cancer cell lines tested. The long alkyl chain attached to the six-position of the heterocyclic ring of 1 appears to be necessary for the observed biological activity.

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