Reactions of ring-expanded xanthines containing the imidazo[4,5-e][1,4]diazepine ring system
โ Scribed by Anila Bhan; Ramachandra S. Hosmane
- Book ID
- 112130787
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1993
- Tongue
- English
- Weight
- 781 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract The synthesis of 6โaminoโ4,5โdihydroโ8__H__โ1โ(2โphosphonylmethoxyethyl)imidazo[4,5โ__e__][1,3]diazepineโ4,8โdione (7), a novel ringโexpanded (โfatโ) acyclic nucleotide analogue of phosphonomethoxyethylguanine (PMEG), has been reported. It was prepared in 4 steps in 51% overall yield st
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable v
Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC 50 's against prostate, lung, breast, and ovarian cancer