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A New Strategy for Solid-Phase Synthesis of O-Glycopeptides

✍ Scribed by Dipl.-Chem. Tim Bielfeldt; Dipl.-Chem. Stefan Peters; Dr. Morten Meldal; Prof. Dr. Klaus Bock; Prof. Dr. Hans Paulsen

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
366 KB
Volume
31
Category
Article
ISSN
0044-8249

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✦ Synopsis

with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the targeted trisaccharide chain 3 (Table 1).

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A convenient solid-phase synthesis of oligonucleotides conjugated at the 3Ј-end with a tetraphenylporphyrin residue, by means of a new polymeric support bearing as a linker a lysine derivative, has been developed. A porphyrin linked