A New Strategy for Solid-Phase Synthesis
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Dipl.-Chem. Tim Bielfeldt; Dipl.-Chem. Stefan Peters; Dr. Morten Meldal; Prof. D
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Article
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1992
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John Wiley and Sons
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English
⚖ 366 KB
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with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target