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A Novel Allylic Anchor for Solid-Phase Synthesis—Synthesis of Protected and Unprotected O-Glycosylated Mucin-Type Glycopeptides

✍ Scribed by Dipl.-Chem. Oliver Seitz; Prof. Dr. Horst Kunz


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
362 KB
Volume
34
Category
Article
ISSN
0044-8249

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A New Strategy for Solid-Phase Synthesis
✍ Dipl.-Chem. Tim Bielfeldt; Dipl.-Chem. Stefan Peters; Dr. Morten Meldal; Prof. D 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB 👁 1 views

with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target