The new organosilane 4-triallylsilylphenol (1) can be synthesised in high yield via two routes using either 4-bromophenol or its silyl-group protected derivative as starting materials. Compound 1 can be used in the divergent or convergent synthesis of carbosilane dendrimers or conversely as a readil
A new solid-supported iterative divergent/convergent strategy for the synthesis of dendrimers
β Scribed by Chunyan Chi; Jishan Wu; Xianhong Wang; Xiaojiang Zhao; Ji Li; Fosong Wang
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 121 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A rapid and convenient solid-supported iterative divergent/convergent approach was developed to prepare rigid phenylacetylene dendrimers. The generation number grows very rapidly and the purification at each step is very simple.
π SIMILAR VOLUMES
A divergent route for the synthesis of carbosilane wedges containing either a bromine or amine as a focal point has been developed lot the construction of core functionalised dendrimers; carbosilane dendrimers up to the third generation containing a 1,3,5benzene triamide core capable of binding gues
Automated solid phase synthesis of 2'-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)TT and d(Tp)3(CBZp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF.
with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target