with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target
A new solid phase strategy for the synthesis of mammalian glucagon
β Scribed by N.A. Abraham; G. Fazal; J.M. Ferland; S. Rakhit; J. Gauthier
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 216 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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