✦ LIBER ✦

A new solid support for polypeptide synthesis

✍ Scribed by W. Parr; K. Grohmann

Publisher: Elsevier Science
Year: 1971
Tongue: French
Weight: 187 KB
Volume: 12
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)96937-0

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✦ Synopsis

The discovery of the solid-phase synthesis by Merrifield (1) opened a new way in the synthesis of polypeptides. However, since the chlorobenzyl-qrouas are uniformly distributed throughout the polystyrene-resin particles (2), all reaction rates are unfavorably controlled by diffusion. This distribution cannot be overcome by using resins with lower concentration of chlorobenzyl groups. A second difficulty arises from using different solvents during reaction and washing steps which cause different swelling of resin particles, thus affecting reaction rate, yields in coupling steps, and purity of synthesized peptides (3,4). Differential swelling of the polymer parti-

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