A new route to sequential polypeptides combining solid phase synthesis and solution peptide synthesis
✍ Scribed by Josette Verhaeghe; Eric Lacassie; Marylène Bertrand; Yves Trudelle
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 238 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
In the synthesis of large peptides or proteins, highly homogeneous segments are indispensable for a convergent strategy either on a solid-phase resin or in solution. Employing Boc/Bzl chemistry to prepare fully protected segments with a free h-carboxyl group from the solid support, base-labile linke
## Abstract In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1–3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. l‐ or D‐ornithine and the nucleobase thymine were linked by a carboxymethylene spacer