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Synthesis of a New Chiral Peptide Analogue of DNA Using Ornithine Subunits and Solid-phase Peptide Synthesis Methodologies

โœ Scribed by Lioy, Eduardo ;Kessler, Horst

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
433 KB
Volume
1996
Category
Article
ISSN
0947-3440

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โœฆ Synopsis

Abstract

In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1โ€“3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. lโ€ or Dโ€ornithine and the nucleobase thymine were linked by a carboxymethylene spacer giving the chiral monomers lโ€7 and Dโ€7. The SPPS was performed according to the Fmoc strategy.

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